Dangers lurk at every turn in Dopeman Volume 1. Ryo Yoshigami eradicates the metropolitan Japan that we know, as it has now become a warzone for the authorities and a new enemy.

The legalization of narcotics unleashed a wave of supernatural powers among drug addicts. To battle the new enemies, the D-Unit is formed comprising of detectives, who alongside the reader, are plunged into a superhuman doping conflict.