Eyeshield 21 volume 22 features story by Riichiro Inagaki and art by Yusuke Murata.

The Kanto Tournament grudge match between the Devil Bats and the nearly unstoppable Shinryuji Nagas rages on, and if Deimon is to have even the slightest hope of winning, it must shut down Shinryuji's offense. But with Naga ace running back Agon slicing through the Deimon linemen like they aren't even there, the Devil Bats are forced to use up their final timeout in a desperate attempt to let Sena's overworked legs cool off. If he pushes himself too hard, Sena might wind up with a permanent injury - so why is Hiruma sending him after Agon?!