Honey and Clover Season 2 contains episodes 1-12 of the anime directed by Tatsuyuki Nagai.

Yuta returns from his journey of self-discovery only to find everyone around him deep in their own struggles to shape their futures. Ayumi finds herself increasingly included in projects involving Takumi and Rika, and the strain is breaking her. Far away in America, Shinobu and his brother's endless quest for money finally helps them achieve their ultimate goal, while back home Hagumi must face the devastating consequences of an accident that could change her life forever. Can the pursuit of happiness and the pursuit of art ever be one and the same?